A) Organization of the nervous system - Introduction to Neuroscience
Santiago Ramon y Cajal
For anyone who is interested, there is a short biopic in Nature Reviews - Neuroscience of Ramon y Cajal, written by Rodolfo Llinas
B) Cells and Synaptic function
Alan Hodgkin Andrew Huxley
The synapse
Charles Sherrington
The Post synaptic cell and ligand gated receptors
Charles Stevens
Modulation, Inhibition and Metabotropic receptors
Michael Berridge
Rita Levi-Montalcini
Tim Bliss
Messages
The exam will be held at 1pm on Thursday December 9th at 1 pm
Fall 2010 Syllabus (PDF file)
Class Schedule
A) Organization of the nervous system
1. Fine structure – Neurohistology (Wirtshafter) 08/25
2. Summary and Discussion (Wirtshafter) 08/27
B) Cells and synaptic function
3. Membrane potentials (Alford) 08/30
4. Action potentials (Alford) 09/01
5. Action potentials contd. (Alford) 09/03
6. Synaptic signaling (Richmond) 09/08
7. The presynaptic terminal – fast synaptic transmission (Richmond) 09/10
8. The presynaptic terminal – fast synaptic transmission (Richmond) 09/13
9. The postsynaptic terminal – fast synaptic transmission (Richmond) 09/15
10. Neuroendocrine cells-vesicle cyling (Gong) 09/17
11. Neuroendocrine cells-vesicle cyling (Gong) 09/20
12. Ligand gated ion channels (excitation) (Alford) 09/22
C) Ligand gated channels
13. Ligand gated ion channels (inhibition) (Alford) 09/24
14. Ligand gated ion channels (inhibition) (Alford) 09/27
15. Discussion and Review (Alford) 09/29
D) Signal Transduction
16. Biogenic amines, neuropeptides, synthesis packaging (Alford) 10/01
17. Neuromodulation and modulators (Alford) 10/04
Pre exam summary 10/06
Exam 1 10/08
18. Neurotrophic factors, Tyrosine kinases, cadherins etc (Rasenick) 10/11
19. Heterotrimeric G proteins (Rasenick) 10/13
20. Integration of synaptic structure with the cytoskeleton (Rasenick) 10/15
21. Axon and dendritic protein transport (Brady) 10/18
22. Axon vs dendritic targeting (Brady) 10/20
23. Discussion and Review (Alford) 10/22
E) Neurodevelopment
24. Neuroembryology (Wirtschafter) 10/25
25. Neuroembryology (cont.) (Wirtschafter) 10/27
26. Neuroembryology (cont) (Wirtschafter) 10/29
27. Cell identity: specification of distinct fates (Alfonso) 11/01
28. Cell identity: cont. (Alfonso) 11/03
29. Axonal pathfinding (Alfonso) 11/05
30. Synapse formation and stabilization (Alfonso) 11/08
31. Synapse formation…. (cont) (Alfonso) 11/10
32.Discussion and Review 11/12
33. Society for Neuroscience Annual Meeting 11/15
34. Society for Neuroscience Annual Meeting 11/17
F) Plasticity and Integration
35. Synaptic Integration (Alford) 11/19
36. Plasticity and integration (Alford) 11/22
37. Synaptic plasticity (Alford) 11/24
Thanksgiving
38. Mood and Modulation (Murphy) 11/29
39. Modulators and Disorders of Mind (Murphy) 12/01
40. Discussion (Alford) 12/3
Final Exam 12/8ish
